{"id":8550,"date":"2020-12-28T04:33:36","date_gmt":"2020-12-28T09:33:36","guid":{"rendered":"http:\/\/esterlund.com\/blog\/?p=8550"},"modified":"2020-12-28T04:34:58","modified_gmt":"2020-12-28T09:34:58","slug":"yes-they-can-vaccinate-us-through-nasal-test-swabs-and-target-the-brain-silview-media","status":"publish","type":"post","link":"https:\/\/esterlund.com\/blog\/yes-they-can-vaccinate-us-through-nasal-test-swabs-and-target-the-brain-silview-media\/","title":{"rendered":"Yes, they CAN vaccinate us through nasal test swabs AND target the brain \u2013 SILVIEW.media"},"content":{"rendered":"

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Source: Yes, they CAN vaccinate us through nasal test swabs AND target the brain \u2013 SILVIEW.media<\/a><\/em><\/p>\n

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Inspired by a parasitic worm that digs its sharp teeth into its host\u2019s intestines, Johns Hopkins researchers have designed tiny, star-shaped microdevices that can latch onto intestinal mucosa and release drugs into the body.<\/p>\n

David Gracias, Ph.D., a professor in the Johns Hopkins University Whiting School of Engineering, and Johns Hopkins gastroenterologist Florin M. Selaru, M.D., director of the Johns Hopkins Inflammatory Bowel Disease Center, led a team of researchers and biomedical engineers that designed and tested shape-changing microdevices that mimic the way the parasitic hookworm affixes itself to an organism\u2019s intestines.<\/p>\n

Made of metal and thin, shape-changing film and coated in a heat-sensitive paraffin wax, \u201ctheragrippers,\u201d each roughly the size of a dust speck, potentially can carry any drug and release it gradually into the body.<\/p>\n

The team published results of an animal study this week as the cover article in the journal\u00a0Science Advances<\/em>.<\/p>\n

Gradual or extended release of a drug is a long-sought goal in medicine. Selaru explains that a problem with extended-release drugs is they often make their way entirely through the\u00a0gastrointestinal tract<\/a>\u00a0before they\u2019ve finished dispensing their medication.<\/p>\n

\u201cNormal constriction and relaxation of GI tract muscles make it impossible for extended-release drugs to stay in the intestine long enough for the patient to receive the full dose,\u201d says Selaru, who has collaborated with Gracias for more than 10 years. \u201cWe\u2019ve been working to solve this problem by designing these small drug carriers that can autonomously latch onto the\u00a0intestinal mucosa<\/a>\u00a0and keep the drug load inside the GI tract for a desired duration of time.\u201d<\/p>\n

RESEARCHERS ENGINEER TINY MACHINES THAT DELIVER MEDICINE EFFICIENTLY<\/h6>\n
NANOPARTICLES FOR NASAL VACCINATION<\/h6>\n
NANONEUROTHERAPEUTICS APPROACH INTENDED FOR DIRECT NOSE TO BRAIN DELIVERY<\/h6>\n
NANOEMULSION-BASED INTRANASAL DRUG DELIVERY SYSTEM OF SAQUINAVIR MESYLATE FOR BRAIN TARGETING<\/h6>\n
HYDROGEL NANOPARTICLES AND NANOCOMPOSITES FOR NASAL DRUG\/VACCINE DELIVERY<\/h6>\n

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Source: Yes, they CAN vaccinate us through nasal test swabs AND target the brain \u2013 SILVIEW.media Inspired by a parasitic worm that digs its sharp teeth into its host\u2019s intestines, Johns Hopkins researchers have designed tiny, star-shaped microdevices that can latch onto intestinal mucosa and release drugs into the body. David Gracias, Ph.D., a professor … Continue reading Yes, they CAN vaccinate us through nasal test swabs AND target the brain \u2013 SILVIEW.media<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[54,29],"tags":[],"_links":{"self":[{"href":"https:\/\/esterlund.com\/blog\/wp-json\/wp\/v2\/posts\/8550"}],"collection":[{"href":"https:\/\/esterlund.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/esterlund.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/esterlund.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/esterlund.com\/blog\/wp-json\/wp\/v2\/comments?post=8550"}],"version-history":[{"count":2,"href":"https:\/\/esterlund.com\/blog\/wp-json\/wp\/v2\/posts\/8550\/revisions"}],"predecessor-version":[{"id":8555,"href":"https:\/\/esterlund.com\/blog\/wp-json\/wp\/v2\/posts\/8550\/revisions\/8555"}],"wp:attachment":[{"href":"https:\/\/esterlund.com\/blog\/wp-json\/wp\/v2\/media?parent=8550"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/esterlund.com\/blog\/wp-json\/wp\/v2\/categories?post=8550"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/esterlund.com\/blog\/wp-json\/wp\/v2\/tags?post=8550"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}